Effects of moderate exercise intensity on serum nesfatin-1 levels in young females

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  • Serhat Özdenk
  • İrfan Kurudirek




Aerobic exercise, nesfatin-1, creatine kinase, energy regulation


Purpose: Nesfatin-1 is known as an energy regulatory hormone. Exercise induced increase in nesfatin-1 levels has been considered as powerful mechanism against metabolic disorders. In this study we evaluated the effects of moderate exercise intensity on serum nesfatin-1 levels in young females.

Material and Method: Total of 12 females performed a 45 minutes of running exercise at their 70% of maximal heart rate. Venous blood samples were taken before and after exercise. Muscle activity condition were evaluated using serum creatine kinase levels (CK). Nesfatin-1 levels measured using enzyme linked-immunosorbent assay (ELISA) method. CK level was measured using autoanalyser. Paired t-test was used to analyse data for significance.

Results: Nesfatin-1 levels increased from baseline value of 159.9±18 ng/mL to 178.2±20 ng/mL to end of exercise (increase of 11%) (p<0.005). In addition, during exercise CK increased significantly from 115.5±20 U/L to 146.7±28 U/L (p<0.05). During exercise, there was no significant correlation between increase of nesfatin-1 and CK levels. There was a positive correlation between nesfatin-1 and fat mass (R=0.66602, P=0.01). Consequently, moderate intensity aerobic exercise induced muscle strain may cause elevate CK levels and stimulate increase in nesfatin-1 levels.

Conclusion: Thus, exercise is an important tool that may have additional effects on energy regulation via affecting nesfatin-1 secretion in young females.


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How to Cite

Özdenk, S., & Kurudirek, İrfan. (2021). Effects of moderate exercise intensity on serum nesfatin-1 levels in young females. Kastamonu Medical Journal, 1(3), 67–70. https://doi.org/10.51271/KMJ-0016