The effects of maternal zinc deficiency on myometrial contractility: an in vitro study
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Keywords:Zinc, myometrium, contractility, rat
Aim: The aim of the study is to investigate the effects of zinc-supplemented or zinc-deficient diet on myometrial contractility during pregnancy.
Material and Method: The patients were divided in four groups as Group 1 (n=5) fed with zinc-deficient diet, Group 2 (n=5) fed with zinc-supplemented diet, Group 3 (n=5) fed with normal diet, and Group 4 (n=5) as the control group and in vitro contractility study was conducted in the myometrial samples taken from these four groups, and intergroup comparison was performed for the results. The p<0.05 was accepted as significant.
Results: In the evaluation of the contractility data, it was determined that the strength and period of contraction and also the frequencies increased in the zinc-supplemented group compared to the other groups. The difference was found to be significant only in frequency ( p<0.05). In the intergroup comparison, the frequency was found to be significantly higher in the zinc-supplemented group than all the other groups ( p<0.05).
Conclusion: This in vitro finding can indicate the importance of zinc supplementation during pregnancy for postpartum bleeding.
Baltaci AK, Mogulkoc R, Baltaci SB. Review: The role of zinc in the endocrine system. Pak J Pharm Sci 2019; 32: 231-9.
Arao Y, Korach KS. The physiological role of estrogen receptor functional domains. Essays Biochem 2021; EBC20200167.
Ruz M, Carrasco F, Rojas P, Basfi-Fer K, Hernández MC, Pérez A. Nutritional Effects of Zinc on Metabolic Syndrome and Type 2 Diabetes: Mechanisms and Main Findings in Human Studies. Biol Trace Elem Res 2019; 188: 177-88.
Rohmawati L, Keumala Sari D, Sitepu M, Rusmil K. A randomized, placebo-controlled trial of zinc supplementation during pregnancy for the prevention of stunting: analysis of maternal serum zinc, cord blood osteocalcin and neonatal birth length [published online ahead of print, 2021 Aug 1]. Med Glas (Zenica) 2021; 18: 10.17392/1267-21.
Kumar V, Kumar A, Singh K, Avasthi K, Kim JJ. Neurobiology of zinc and its role in neurogenesis. Eur J Nutr 2021; 60: 55-64.
Al-Sakarneh NA, Mashal RH. Evaluation of Zinc and Homocysteine Status in Pregnant Women and Their Association with Pre-eclampsia in Jordan. Prev Nutr Food Sci 2021; 26: 21-9.
Abu-Saad K, Kaufman-Shriqui V, Freedman LS, Belmaker I, Fraser D. Preconceptional diet quality is associated with birth outcomes among low socioeconomic status minority women in a high-income country. Eur J Nutr 2021; 60: 65-77.
Li M, Grewal J, Hinkle SN, et al. Healthy dietary patterns and common pregnancy complications: a prospective and longitudinal study [published online ahead of print, 2021 Jun 2]. Am J Clin Nutr 2021; 114: 1229-37.
Staub E, Evers K, Askie LM. Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates. Cochrane Database Syst Rev 2021; 3: CD012797.
Georgieff MK. Iron deficiency in pregnancy. Am J Obstet Gynecol 2020; 223: 516-24.
Brion LP, Heyne R, Lair CS. Role of zinc in neonatal growth and brain growth: review and scoping review. Pediatr Res 2021; 89: 1627-40.
Zahiri Sorouri Z, Sadeghi H, Pourmarzi D. The effect of zinc supplementation on pregnancy outcome: a randomized controlled trial. J Matern Fetal Neonatal Med 2016; 29: 2194-8.
Sanusi KO, Ibrahim KG, Abubakar B, et al. Effect of maternal zinc deficiency on offspring health: The epigenetic impact. J Trace Elem Med Biol 2021; 65: 126731.
Carducci B, Keats EC, Bhutta ZA. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev 2021; 3: CD000230.
Dumrongwongsiri O, Winichagoon P, Chongviriyaphan N, Suthutvoravut U, Grote V, Koletzko B. Effect of Maternal Nutritional Status and Mode of Delivery on Zinc and Iron Stores at Birth. Nutrients 2021; 13: 860.
Garner TB, Hester JM, Carothers A, Diaz FJ. Role of zinc in female reproduction. Biol Reprod 2021; 104: 976-94.
Pessina F, Solito R, Maestrini D, Gerli R, Sgaragli G. Effect of anoxia-glucopenia and re-superfusion on intrinsic nerves of mammalian detrusor smooth muscle: importance of glucose metabolism. Neurourol Urodyn 2005; 24: 389-96.
Alotaibi MF. Effects of Intermittent and Continuous Oxytocin Exposure on Myometrial Contractile Activity in Term-Pregnant Rats In Vitro. Reprod Sci 2020; 27: 1024-9.
Orieke D, Ohaeri OC, Ijeh II, Ijioma SN. Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of corchorus olitorius leaf extract in laboratory animal models. J Ethnopharmacol 2020; 247: 112224.
Malik M, Roh M, England SK. Uterine contractions in rodent models and humans. Acta Physiol (Oxf) 2021; 231: e13607.
Urquhart C, Currell R, Harlow F, Callow L. Home uterine monitoring for detecting preterm labour. Cochrane Database Syst Rev 2017; 2: CD006172.
Yasuda K, Yoshida A, Okada H. Conflicting Nongenomic Effects of Progesterone in the Myometrium of Pregnant Rats. Int J Mol Sci 2021; 22: 2154.
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