The essential role of nesfatin-1 as a biological signal on the body systems

Abstract views: 173 / PDF downloads: 44


  • Sermin Algül
  • Erhan Dinçer Van Yüzüncü Yıl University, Faculty of Medicine, Department of Physilogy, Van, Turkey



Nesfatin-1, biological signal, exercise, stress, obesity, metabolism


Nesfatin-1is first described in 2006 as an anorectic peptide and regulate food intake. In following years, the studies demonstrated the presence of nesfatin-1 in central and various peripheral tissues. Thus, nesfatin-1 popularity increasing widely in clinical medicine, especially in cardiology, neurology, reproduction, metabolic disorders, psychiatric disorders, gastrointestinal system. Today, the main point concerning nesfatin-1 action in body organ and systems is concentrate its biological signals effects. Thus the increasing knowledge in these area will be highlighted for future studies especially in serious health problem all over the world population.


Oh-I S, Shimizu H, Satoh T, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006; 443: 709-12.

Gok Yurtseven D, Minbay Z, Eyigör Ö. Anorexigenic peptide in the control of food intake: Nesfatin-1. J Uludag Uni Med Faculty 2018; 44: 135-42.

Kim J, Yang H. Nesfatin-1 as a New Potent Regulator in Reproductive System. Dev Reprod 2012; 16: 253-64.

Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, et al. Peripheral administration of nesfatin-1 reduces food intake in mice: The leptin-independent mechanism. Endocrinology 2009; 150: 662-71.

Stengel A, Taché Y. Nesfatin-1 - Role as possible new potent regulator of food intake. Regul Pept 2010; 163: 18-23.

Morton KA, Hargreaves L, Mortazavi S, Weber LP, Blanco AM, Unniappan S. Tissue Specific expression and circulating concentrations of nesfatin-1 in domestic animals. Domest Anim Endocrinol 2018; 65: 56-66.

Ayada C, Toru U, Korkut Y. Nesfatin-1 and its effects on different systems. Hippokratia 2015; 19: 4-10.

Schalla MA, Stengel A. Current Understanding of the Role of Nesfatin-1. J Endocr Soc 2018; 2: 1188-1206.

Stengel A, Goebel M, Yakubov I, et al. Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 2009; 150: 232-8.

Dai H, Li X, He T, Wang Y, et al. Decreased plasma nesfatin-1 levels in patients with acute myocardial infarction. Peptides 2013; 46: 167-71.

Angelone T, Filice E, Pasqua T, et al. Nesfatin-1 as a novel cardiac peptide: Identification, functional characterization, and protection against ischemia/reperfusion injury. Cell Mol Life Sci 2013; 70: 495-509.

Angelone, Tommaso, Rocca C, Pasqua T. Nesfatin-1 in cardiovascular orchestration: From bench to bedside. Pharmacol Res 2020; 156: 104766.

Yosten GLC, Samson WK. Nesfatin-1 exerts cardiovascular actions in brain: Possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol 2009; 297: 330-6.

Sahin FK, Sahin SB, Ural UM, et al. Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome. Bosn J Basic Med Sci 2015; 15: 57-63.

Feijóo-Bandín S, Rodríguez-Penas D, García-Rúa V, Mosquera-Leal A, González-Juanatey JR, Lago F. Nesfatin-1: a new energy-regulating peptide with pleiotropic functions.Implications at cardiovascular level. Endocrine 2016; 52: 11-29.

Guo FF, Xu L, Gao SL, Sun XR, Li ZL, Gong YL. The effects of nesfatin-1 in the paraventricular nucleus on gastric motility and its potential regulation by the lateral hypothalamic area in rats. J Neurochem 2015; 132: 266-75.

Stengel A. Nesfatin-1 - More than a food intake regulatory peptide. Peptides 2015; 72: 175-83.

Kolgazi M, Cantali-Ozturk C, Deniz R, et al. Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms. J Surg Res 2015; 193: 111-8.

Szlachcic A, Sliwowski Z, Krzysiek-Maczka G, et al. New satiety hormone nesfatin-1 protects gastric mucosa against stress-induced injury: Mechanistic roles of prostaglandins, nitric oxide, sensory nerves and vanilloid receptors. Peptides 2013; 49: 9-20.

Emmerzaal T, Kozicz T. Nesfatin-1; Implication in stress and stress-associated anxiety and depression. Curr Pharm Des 2013; 19: 6941-8.

Pałasz A, Janas-Kozik M, Borrow A, Arias-Carrión O, Worthington JJ. The potential role Of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa. Neurochem Int 2018; 113: 120-36.

Wei Y, Li J, Wang H, Wang G. NUCB2/nesfatin-1: Expression and functions in the regulation of emotion and stress. Prog Neuropsychopharmacol Biol Psychiatry 2018; 81: 221-7.

Unal K, Yüksel RN, Turhan T, Sezer S, Yaylaci ET. The association of serum nesfatin-1 and ghrelin levels with metabolic syndrome in patients with schizophrenia. Psychiatry Res 2018; 261: 45-49.

Algul S, Ozcelik O. Evaluating the levels of nesfatin-1 and ghrelin hormones in patients with moderate and severe major depressive disorders. Psychiatry Investi 2018; 15: 214-218.

Liu M, Shen X, Du X, Jiang H. Plasma levels of nesfatin-1 as a new biomarker in depression in Asians: evidence from meta-analysis. Biomarkers 2020; 25: 228-34.

Sahpolat M, Ari M. Plasma nesfatin 1 level in patients with first attack psychosis. Bratisl Lek Listy 2017; 118: 77-9.

Riva M, Nitert MD, Voss U, et al. Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects. Cell Tissue Res 2011; 346: 393-405.

Zhai T, Li SZ, Fan XT, Tian Z, Lu XQ, Dong J. Circulating nesfatin-1 levels and type 2 diabetes: A systematic review and meta-analysis. J Diabetes Res 2017; 2017: 7687098.

Tekin T, Cicek B, Konyaligil N. Regulatory peptide Nesfatin-1 and its relationship with metabolic syndrome. Eurasian J Med 2019; 51: 280-84.

Shen P, Han Y, Cai B, Wang Y. Decreased levels of serum nesfatin-1 in patients with obstructive sleep apnea syndrome. Sleep Breath 2015; 19: 515-22.

Ergul Erkec O, Algul S, Kara M. Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate. Neurol Res 2018; 40: 923- 9.

Pałasz A, Krzystanek M, Worthington J, et al. Nesfatin-1, a unique regulatory neuropeptide of the brain. Neuropeptides 2012; 46: 105-12.

Liu Z, Wang F, Li ZZ, et al. Expression of neuropeptides ghrelin and nesfatin-1 in kainic acid-kindling rats. Zhonghua Yi Xue Za Zhi 2011; 22: 496-500.

İsguzar Y, Akbulut G. Two Current Hormones Related to Obesity: Nesfatin-1 and Omentin-1. Turkiye Klinikleri J Health Sci 2019; 4: 57-61.

Catli G, Abaci A, Anik A, Bober E. Low serum nesfatin-1 levels may be a contributing factor for monogenic obesity due to prohormone convertase 1 deficiency. Med Hypotheses 2013; 81: 172-4.

Schalla MA, Unniappan S, Lambrecht NWG, Mori M, Taché Y, Stengel A. NUCB2/nesfatin- 1 Inhibitory effects on food intake, body weight and metabolism. Peptides 2020; 128: 170308.

Yin Y, Li Z, Gao L, Li Y, Zhao J, Zhang W. AMPK-dependent modulation of hepatic lipid metabolism by nesfatin-1. Mol Cell Endocrinol 2015; 417: 20-6.

Chen D, Cao S, Chang B, et al. Increasing hypothalamic nucleobindin 2 levels and decreasing hypothalamic inflammation in obese male mice via diet and exercise alleviate obesity-associated hypogonadism. Neuropeptides 2019; 74: 34-43.

Algul S, Ozcelik O. Acute determination of the effects of acute aerobic exercise on nesfatin-1 levels. FU Med J Health Sci 2016; 30: 5-8.

Ozcelik O, Algul S, Yilmaz B. Nesfatin-1 and irisin levels in response to the soccer matches performed in morning, afternoon and at night in young trained male subjects. Cell Mol Biol (Noisy-Le-Grand) 2018; 64: 130-3.

Algul S, Ozdenk C, Ozcelik O. Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects. Biol Sport 2017; 34: 339-44.

Ghanbari-Niaki A, Kraemer RR, Soltani R. Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. Eur J Appl Physiol 2010; 110: 863-8.

Özdenk C. Determination of effects of exercise at anaerobic threshold on nesfatin-1 hormone in trained male subjects. J Health Sci 2018; 27: 132-6.

Mohebbi H, Nourshahi M, Ghasemikaram M, Safarimosavi S. Effects of exercise at individual anaerobic threshold and maximal fat oxidation intensities on plasma levels of nesfatin-1 and metabolic health biomarkers. J Physiol Biochem 2015; 71: 79-88.

Yazici AG. Relationship and interaction between anaerobic sports branches and serum Nesfatin-1. Turk J Phys Med Rehab 2015; 61: 234-40.

Arikan S. Effects of acute and chronic exercises on plasma nesfatin-1 levels in young adults. Cyprus J Med Sci 2020; 5: 77-80.

Uğraş S, Özçelik O. Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males. Turk Hij Den Biyol Derg 2020; 77: 227-32.

Chaolu H, Asakawa A, Ushikai M, et al. Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Exp Ther Med 2011; 2: 369-73.

Jabar B, Farhad G, Adel R, Vahid T. Effect of single bout of aerobic exercise on serum nesfatin-1 levels in non-athlete elderly men. M J Tabriz Univ Med Sci 2012; 34: 25-30.

Ahmadizad S, Avansar AS, Ebrahim K, Avandi M, Ghasemikaram M. The effects of short term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers. Horm Mol Biol Clin Investig 2015; 21: 165-73.

Shirvani H, Rahmati-Ahmadabad S. Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement. Lipids Health Dis 2019; 18: 15.

Haghshenas R, Jafari M, Ravasi A, et al. The effect of eight weeks endurance training and high-fat diet on appetite-regulating hormones in rat plasma. Iran J Basic Med Sci 2014; 17: 237-43.

Mogharnasi M, Taheri Chadorneshin H, Papoli-Baravati SA, Teymuri A. Effects of upper-body resistance exercise training on serum nesfatin-1 level, insulin resistance, and body composition in obese paraplegic men. Disabi Health J 2019; 12: 29-34.

Jafari M, Mogharnasi M. The protective effect of different methods of exercise training on plasma levels of nesfatin-1, cardiorespiratory endurance and body composition in overweight and obese females. Mod Care J 2015; 12: 61-7.

Tabas AT, Mogharnasi M. The effect of 10 week resistance exercise training on serum levels of nesfatin-1 and insulin resistance index in woman with type 2 diabetes. Iran J Diabetes Metab 2016; 14: 179-88.

Uğraş S, Dalkılıç M. Effects of aerobic exercise induced oxidative stress on energy regulatory hormones of irisin and nesfatin-1 in healthy females. Kastamonu Med J 2021; 1: 5-8

Özdenk S, Kurudirek İ. Effects of moderate exercise intensity on serum nesfatin-1 levels in young females. Kastamonu Med J 2021; 1: 67-70




How to Cite

Algül, S., & Dinçer, E. . (2022). The essential role of nesfatin-1 as a biological signal on the body systems. Kastamonu Medical Journal, 1(4), 113–118.